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Red meat accelerator carcinogenic risk

สารเร่งเนื้อแดง เสี่ยงสารก่อมะเร็ง

Red meat accelerator carcinogenic risk

    For Thailand, there is an announcement in the Ministerial Regulations of Agriculture and Cooperatives. “Do not use red meat accelerators in pig farming is strictly prohibited.” Anyone smuggling it is considered illegal, with heavy penalties and fines. This is in accordance with the announcement of the Ministry of Agriculture and Cooperatives B.E. 2545 until the revision of the announcement in 2016 regarding the determination of raw materials prohibited to be used as ingredients in animal feed. including the announcement of the Ministry of Public Health, B.E. 2546
 

What is red meat accelerator? 

and pharmacokinetics of red meat accelerators
 
     Red meat accelerators or substances in the beta-agonist group are substances in the group. Catecholamine which has a structural formula similar to Noradrenaline Can act as both a neurotransmitter and a hormone by binding to specific receptors on the cell surface (Beta receptor). There are two types of receptors on the cell surface: beta1 (ß1) and beta2 (ß2). Days are found at the heart and nervous system. Beta II receptors are found in blood vessels. gastrointestinal tube Fat cells and muscle cells can be absorbed well by eating. After entering the body, it reaches the highest concentration in the blood within 2.5 hours, with
 
 
The elimination half-life in the blood is approximately 2.7-7 hours, then most is metabolite by the liver and eliminated mainly by the kidneys. It is eliminated from the body by 72% of the dose administered within 24 hours in the urine and has an elimination half-life of approximately 4 hours in the blood (Douglas Pharmaceutical Ltd, 1999).
 

Specimen and red meat accelerators

 
At present, there are many drugs and chemicals classified as red meat accelerators such as Salbutamol, Clenbuterol, Bromobuterol, Cimbuterol, Mapenterol, Mabuterol, Tolobuterol, Clenpenterol, Clenproperol, Terbutaline, Carbuterol, Cimaterol and Ractopamine etc.
 

The action of red meat accelerators

 
It was found that salbutamol had an effect on reducing feed intake for pigs. It improved the feed conversion rate to swine weight (Sompot et al., 1995; Hansen et al., 1997) and resulted in a decrease in the percentage of total fat and total bone in the carcass but the percentage of red meat in the carcass increased. (Sompot et al., 1995 ; Warriss et al., 1990 ; Yen al., 1990)
 

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Disadvantages and dangers of using red meat accelerators
    cause side effects on the animal causing the animal to have a faster heartbeat In some animals, myocardial infarction may occur. In addition, the heat generation in the animals increased. As a result, animals are less resistant to heat and may develop heat stress (Ruangyuth, 1993). For humans, the side effects are skeletal muscle spasm, goosebumps, tachycardia, headache, if given in high doses, nausea and vomiting may occur (Renoidand Prasdel, 1982 ref et al., 1996). to treat by
 
     Administered at doses of approximately 0.2-8.8 mg/kg body weight in 78 patients aged 2-8 years, it was found that ingested salbutamol caused toxicity. heart beating faster than normal have higher than normal blood sugar Jitters, vomiting, and low potassium levels in the bloodstream (Wiley et al., 1994; pte et al., 1996) were reported in 1990 in Spain in 135 people who consumed liver. Cattle with clenbuterol residues in it muscle tremors occur fast heartbeat and some have fainting symptoms Psychiatric symptoms were also found.
Nerve, back pain after ingestion of cow liver and symptoms persist for 2-3 days (Yupadi et al., 1996).
 

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Laws related to livestock

 
1. Animal Feed Quality Control Act B.E. 2525 (1982) and amended by the Animal Feed Quality Control Act (No. 2) B.E. import for sale and assign name, type, type, characteristics, properties and
Components of substances added to animal feed that are prohibited to be used as ingredients in animal feed production, 2002, item 2. All types of animal feed containing drugs are not allowed to be imported for sale. pharmaceutical chemicals salt of pharmaceutical chemicals and semi-finished pharmaceutical chemicals Beta agonists It is an ingredient in animal feed. Article 3 Do not use pharmaceutical chemicals. Salt of pharmaceutical chemicals and semi-finished pharmaceutical chemicals Beta agonists It is an added material in animal feed in animal feed production.
 

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2. Ministerial Regulations on Determination of Epidemics Diseases or Characteristics of Animals or Meat Unsuitable to Use Meat as Food, 2003 in the Government Gazette, Volume 120, Part 103a, dated October 15, 2003, Article 2, animals with disease or disease or having the following characteristics: the following It shall be deemed unsuitable to use such meat under Section 23 in (33) Animal with beta-agonist residues Article 3 Meat with disease or having the following characteristics: It shall be deemed unsuitable to use meat as food according to Section 24 in (9), meat containing beta-agonist residues.
 

Discussions about the use of Ractopamine

 
    Regarding the use of ractopamine, the resolution of the International Food Standards Commission (Codex Alimenttarius Commission) refer to the letter for 1010/4/13251. The Department of Livestock Development has considered and commented on the letter No. Kor Kor 0615/4413 by commenting that Regarding the review of the announcement of the Ministry of Public Health Should be consistent with the announcement of the Ministry of Agriculture and Cooperatives. Under the Animal Feed Quality Control Act B.E. and the Ministerial Regulations on prescribing animal epidemics. 
 

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Diseases or characteristics of animals or meat that are unsuitable for using that meat as food, B.E. 2003 under the Animal Slaughter and Meat Sale Act B.E. 1992, which stipulates that animals and meat containing beta-agonist residues are unsuitable for use as food. to prevent the risk of illegal use of such substances which has no information on Internationally accepted levels of residues in organs from animals have been established. While Thai consumers consume all kinds of offal. and those involved in the use of ractopamine, including the Thai Feed Producers Association and the National Swine Raisers Association. has a letter to the Department of Livestock Development that they do not agree with the permission of the use of such substances in Thailand and agree to proceed with the practice of the Department of 
 
Livestock Development Regarding the review of the notification of the Ministry of Public Health for food products imported from swine remark that The standard should not be detected in other types of machines that Codex has not yet defined. And it is prohibited to detect in animal food products produced in Thailand. Ractopamine, including the Thai Feed Mill Association and the National Swine Farmers Association has a letter to the Department of Livestock Development that they do not agree with the permission of the use of such substances in Thailand and agree to proceed with the practice of the Department of Livestock Development Regarding the review of the notification of the Ministry of Public Health for food products imported from swine remark that The standard should not be detected in other types of machines that Codex has not yet defined. 
 

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And it is prohibited to detect in animal food products produced in Thailand. Ractopamine, including the Thai Feed Mill Association and the National Swine Farmers Association has a letter to the Department of Livestock Development that they do not agree with the permission of the use of such substances in Thailand and agree to proceed with the practice of the Department of Livestock Development Regarding the review of the notification of the Ministry of Public Health for food products imported from swine remark that The standard should not be detected in other types of machines that Codex has not yet defined. And it is prohibited to detect in animal food products produced in Thailand. 
 
    for the purpose of prescribing consumer protection measures in the country and export support This will make the standards of food products produced in Thailand remain on par with foreign countries such as the European Union. Studies on residues in pigs of the People’s Republic of China have been considered. It was found that if consumers consumed 300 grams of lungs per day instead of liver and kidneys. Consumers will receive residues in excess of safety standards (ADI: (Acceptable Daily Intake) 
 
 

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An worse case scenario where JECFA is currently used for a day’s consumption of meat with veterinary drug residues is 300 g of muscle, 100 g of liver, 50 g of kidney, and 50 g of fat. Other tissue residue data are available for consideration by JECFA, and there are no criteria for assessing the consumption risk covering other offal. In addition, most drugs are permitted for prophylaxis, not for general animal use to improve carcass quality, like ractopamine. The dose in studies to determine the level of safety from veterinary drug residues is 1 and a half times that of veterinary drug residues. maximum dose (while the pulmonary residue data from the People’s Republic of China study, the maximum dose is administered only) (Bureau of System Development and Certification of Livestock Products, 2013) 
 
 

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Tips for buying pork
 
    Good pork has a pale pinkish-red color, soft, greasy skin, firm flesh, no rotten smell or greenish color, and the hard greasy part should be milky white. Always buy pork from a reliable source. or certified by the Department of Livestock Development Buying chilled pork The date of manufacture should be noted on the package. which should not exceed 3 days from the date of production until the date of purchase Do not buy pork that is too red and has a thin fat. Because there is a high probability of contaminating the red meat accelerator. Pork contaminated with red meat enhancer if cut and left to dry. As for normal pork, when the cut is left, water will seep out on the surface of the three layers. Normal pig meat has two parts red meat to one part fat (33%), but pork with red meat additives has up to three parts red meat per one part (25%) fat. That is, it has more red meat than it is. (Department of Livestock Development, 2011)
 
 
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